This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McCormick, W. Articles by Penman, S. Search for Related Content PubMed PubMed Citation Articles by McCormick, W. Articles by Penman, S.

Replication of Mengovirus in HeLa Cells Preinfected with Nonreplicating Poliovirus

Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02139

ABSTRACT

The replication of mengovirus in HeLa cells preinfected with poliovirus in the presence of 10^–3 M guanidine was investigated. Although host cell protein synthesis is inhibited by the presence of nonreplicating poliovirus, it is found that mengovirus ribonucleic acid (RNA) and protein synthesis proceed normally under the same conditions. Furthermore, no effects on mengovirus growth by poliovirus can be detected either when Mengo protein synthesis is interrupted by Acti-Dione or when its RNA synthesis is reduced by incubation at 28 C. It is suggested that the poliovirus inhibitory factor may be able to distinguish between an RNA element required in the protein-synthesizing apparatus of the host cell and a comparable element in that of the heterologous virus.

This article has been cited by other articles:

• Fata-Hartley, C. L., Palmenberg, A. C. (2005). Dipyridamole Reversibly Inhibits Mengovirus RNA Replication. J. Virol. 79: 11062-11070 [Abstract] [Full Text]