This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Pfefferkorn, E. R. Articles by Coady, H. M. Search for Related Content PubMed PubMed Citation Articles by Pfefferkorn, E. R. Articles by Coady, H. M.

 Previous Article  |  Next Article 

J Virol. 1968 May; 2(5): 474-479
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Mechanism of Photoreactivation of Pseudorabies Virus

Department of Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts 02115

ABSTRACT

Primary chick embryo cultures were able to photoreactivate ultraviolet-treated pseudorabies virus. Upon exposure to fluorescent light, infected or uninfected chick cells eliminated thymine dimers induced in their deoxyribonucleic acid by ultraviolet irradiation. In contrast, rabbit kidney cells did not photoreactivate the virus or eliminate thymine dimers. Thus, the capacity for photoreactivation appeared to be determined by the ability of the cell to eliminate thymine dimers.

¹ Present address: Microbiology Department, Dartmouth Medical School, Hanover, N.H. 03755.