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J Virol. 1968 November; 2(11): 1315-1325
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Electron Microscopic Observations of Mouse Brain Infected with Bunyamwera Group Arboviruses

National Communicable Disease Center, Health Services and Mental Health Administration, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333

ABSTRACT

Ultrathin sections of brain tissue from mice infected with three Bunyamwera group arboviruses, Bunyamwera, Tensaw, and Maguari, were examined by electron microscopy. In all three cases, virus was observed budding from membranes into intracytoplasmic cisternae. Mature virus was found accumulated within these distended cisternae and in extracellular spaces. The three viruses were morphologically indistinguishable; particles were round or oval, 98 nm in diameter, and had a closely adherent irregular envelope.

¹ Present address: Medical Sciences Laboratory, Fort Detrick, Frederick, Md.