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J Virol. 1968 November; 2(11): 1241-1248
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Cellular Origin of a Mouse Leukemia Viral Ribonucleic Acid

Departments of Pathology and Pediatrics, The University of Chicago, Chicago, Illinois 60637

ABSTRACT

Mouse erythroblastosis virus, a member of the mouse leukemia virus group, was obtained from chronically infected C₃H mouse embryo cells and purified on sucrose gradients. The ribonucleic acid (RNA) extracted from ribonuclease-treated virus consisted of a rapidly sedimenting (72S) species and a more slowly sedimenting component (4 to 30S). The 72S RNA did not contain base sequences homologous to deoxyribonucleic acid (DNA) from infected cells as determined by hybridization studies. In contrast, the slowly sedimenting RNA enclosed within the virus had base sequences homologous to DNA from infected and uninfected C₃H mouse embryo cells.

¹ Predoctoral Trainee, training grant 5 TO1-HD-0001 from the National Institute of Child Health and Human Development.

² NIH Career Development Awardee.