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J Virol. 1976 July; 19(1): 279-285

Excision of viral DNA from host cell DNA after induction of simian virus 40-transformed hamster cells.

T Rakusanova, J C Kaplan, W P Smales and P H Black

ABSTRACT

Simian virus 40-transformed hamster cells were induced to produce infectious virus by treatment with mitomycin C or gamma-irradiation. A portion of the simian virus-40 DNA, which is integrated into the host cell genome in uninduced cells, was recovered in a pool of relatively low-molecular-weight DNA early after induction treatment in the absence of DNA replication. The data indicte that excision of the viral genome occurs subsequent to the induction stimulus.

J Virol. 1976 July; 19(1): 279-285






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