This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schilling, R Articles by Winnacker, E L Search for Related Content PubMed PubMed Citation Articles by Schilling, R Articles by Winnacker, E L

 Previous Article  |  Next Article 

J Virol. 1975 October; 16(4): 767-774

Adenovirus type 2 DNA replication. II. Termini of DNA replication.

ABSTRACT

Complete, mature adenovirus type 2 DNA molecules were isolated from virus-infected HeLa cells, pulse-labeled at 20 h postinfection in [3H]thymidine pulses shorter than the time necessary for one round of viral DNA replication. After digestion with the restriction endonucleases Eco RI, Hpa I, and Hind III, a temporal order of synthesis of different regions of the viral genome was established from the relative specific radioactivities in the restriction enzyme fragments. A comparison with the physical order of these fragments revealed the existence of two termini of DNA replication towards both the molecular right and left ends, respectively, of the viral chromosome.

This article has been cited by other articles:

• van Breukelen, B., Brenkman, A. B., Holthuizen, P. E., van der Vliet, P. C. (2002). Adenovirus Type 5 DNA Binding Protein Stimulates Binding of DNA Polymerase to the Replication Origin. J. Virol. 77: 915-922 [Abstract] [Full Text]