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J Virol. 1975 August; 16(2): 217-221

Effect of 2-deoxy-D-glucose on herpesvirus-induced inhibition of cellular DNA synthesis.

H Ludwig and R Rott

ABSTRACT

In pseudorabies virus-infected cells host DNA synthesis is turned off 4 to 5 h postinfection. In the presence of 0.5 mM 2-deoxy-D-glucose, however, synthesis of both cellular and viral DNA proceeds unimpaired throughout the virus replication cycle. The uptake of radioactive thymidine into mock-infected cells is not altered in the presence of 2-deoxy-D-glucose. Virus-specific protein synthesis and particle formation also proceed in medium containing the deoxy sugar, but the virus particles produced are noninfectious and cell fusion is inhibited.

J Virol. 1975 August; 16(2): 217-221






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