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J Virol. 1975 May; 15(5): 1284-1285

Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine.

Y C Cheng, B Goz, J P Neenan, D C Ward and W H Prusoff

ABSTRACT

5-Amino-2,5-dideoxy-5-iodouridine, a nel thymidine analogue, is a potent inhibitor of herpes simplex virus type 1 replication. In contrast to most other nucleoside analogues which possess antiviral activity, 5-amino-2,5-dideoxy-5-iodouridine exhibits little, if any, cellular toxicity. Preliminary evidence suggests that 5-amino-2,5-dideoxy-5-iodouridine selectively inhibits viral-specific DNA synthesis.

J Virol. 1975 May; 15(5): 1284-1285






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J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1975 by the American Society for Microbiology. All rights reserved.