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J Virol. 1975 May; 15(5): 1281-1283
Copyright © 1975 American Society for Microbiology. All Rights Reserved.

Inhibition of DNA Polymerase from Herpes Simplex Virus-Infected Wi-38 Cells by Phosphonoacetic Acid

Abbott Laboratories, North Chicago, Illinois 60064

ABSTRACT

Infection of Wi-38 cells with herpes simplex virus induced an elevated DNA polymerase activity which had many biochemical properties different from normal cell DNA polymerase. Phosphonoacetic acid specifically inhibited the virus-induced DNA polymerase as compared to the normal WI-38 cell DNA polymerase. The compound did not appear to inhibit enzyme activity by interacting with the DNA primer.

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