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J Virol. 1975 April; 15(4): 806-811

Differential accumulation of virus-specific RNA during the cell cycle of adenovirus-transformed rat embyro cells.

ABSTRACT

In adenovirus type 2-transformed rat embryo cells there is a threefold greater incorporation of [3-H]uridine into virus-specific RNA early in S phase than in late S or G2. This heightened accumulation of labeled RNA is true for both nuclear and cytoplasmic virus-specific labeling. Inhibition of DNA synthesis decreases the virus-specific RNA labeling, whereas reversal of inhibition again allows the elevated level of virus-specific RNA labeling.