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J Virol. 1975 January; 15(1): 115-120

Antigenic characterization of type C RNA virus isolates of gibbon apes.

ABSTRACT

Type C RNA viruses initially isolated from a lymphosarcoma of a gibbon ape and from a fibrosarcoma of a woolly monkey are very closely related immunologically. However, recent studies have shown that these viruses are distinguishable in a radioimmunoassay for the 12,000-molecular-weight polypeptide (p12) of the woolly monkey virus. In the present report, an immunoassay has been developed for the p12 polypeptide of the gibbon ape type C virus. This assay is shown to further distinguish the woolly monkey and gibbon ape viruses. In type-specific assays for the p12 polypeptides of these viruses, two new type C viruses isolated from gibbons in a second colony, characterized by high incidence of hemopoietic neoplasia, are immunologically distinguishable from the original gibbon ape virus. The p12 type-specific immunoassays described in the present report may be of importance in studying the natural history of these viruses and their relationship to tumors of primates.

This article has been cited by other articles:

• Sen, A, Todaro, G. (1976). Specificity of in vitro binding of primate Type C viral RNA and the homologous viral p12 core protein. Science 193: 326-328 [Abstract]