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J Virol. 1974 November; 14(5): 1274-1280
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Biological Expression of Antigenic Determinants of Murine Leukemia Virus Proteins gp69/71 and p30

H. Ikeda, T. Pincus, T. Yoshiki, M. Strand, J. T. August, E. A. Boyse and R. C. Mellors

The Laboratories of Cell Surface Immunogenetics and Mouse Leukemia Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021
The Hospital for Special Surgery, Affiliated with the New York Hospital, Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, New York 10021
Department of Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461

ABSTRACT

Antisera to purified structural proteins of Rauscher murine leukemia virus, the major envelope glycoprotein, gp69/71, and the major internal protein, p30, were studied by immunofluorescence of viable and fixed virus-infected cells and by virus neutralization. Group-specific and type-specific determinants of gp69/71 were demonstrated by immunofluorescence and virus neutralization tests, indicating that these determinants are located in the cytoplasm and probably on the cell surface as well as on virus envelope. Antisera against p30 showed anti-group and anti-interspecies activities by immunofluorescence with no virus-neutralizing activity. Both antigenic determinants of gp69/71 were sensitive to guanidine-hydrochloride and to a lesser degree to ether treatment, whereas the group-specific determinants of p30 were relatively stable to these treatments.

J Virol. 1974 November; 14(5): 1274-1280
Copyright © 1974 American Society for Microbiology. All Rights Reserved.





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