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J Virol. 1974 November; 14(5): 1076-1082
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Homologous Interference Induced by Sindbis Virus

^a Department of Microbiology, The University of Texas at Austin, Austin, Texas 78712

ABSTRACT

Homologous interference during Sindbis virus infection has been investigated. Prior infection of either chicken embryo fibroblast or BHK₂₁ cell cultures results in reduced yields of progeny virions of the superinfecting genotype. This reduction in yield results from a reduction in the number of cells in the cultures capable of producing the superinfecting genotype. The development of interference parallels the attachment kinetics of Sindbis virus. Interference requires an active viral genome since the activity is sensitive to inactivation by ultraviolet light, and an RNA^– mutant, ts-24, fails to induce interference under nonpermissive conditions. However, ts-6, an RNA^– mutant belonging to a different complementation group, and the RNA⁺ mutants, ts-2 and ts-20, interfere at both permissive and nonpermissive temperatures.

¹ Present address: Department of Microbiology and Immunology, Queens University, Kingston, Ontario, Canada.

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