This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Moreau, M.-C. Search for Related Content PubMed PubMed Citation Articles by Moreau, M.-C.

Inhibition of a Vesicular Stomatitis Virus Mutant by Rifampin

¹ Institut National de la Santé et de la Recherche Médicale, U. 43 Hôpital St.-Vincent-de-Paul, Paris 75014, France

ABSTRACT

Rifampin reversibly inhibits the intracellular replication of a VSV mutant, whereas a revertant variant selected from this viral population, as well as the wild strain, are not affected by this drug. Rifampin inhibits transcriptase activity of the sensitive mutant only and, consequently, total viral RNA synthesis decreases significantly in the cells.