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J Virol. 1974 August; 14(2): 307-314
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Inhibition of Herpes Virus-Induced Cell Fusion by Concanavalin A, Antisera, and 2-Deoxy-D-Glucose

H. Ludwig, H. Becht and R. Rott

Institut für Virologie, Justus Liebig-Universität, Giessen, Germany

ABSTRACT

Pseudorabies virus-induced cell fusion in rabbit kidney cells can be prevented by Concanavalin A added early after infection. The infected cells are not agglutinated and the infectivity of cell-free virus is not reduced. Sera from productively infected animals also inhibit polykaryocytosis, whereas a hyperimmune serum directed against virus structural components has no effect. 2-Deoxy-D-glucose reversibly disturbs virus-induced fusion and reduces significantly the virus infectivity.


J Virol. 1974 August; 14(2): 307-314
Copyright © 1974 American Society for Microbiology. All Rights Reserved.







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Copyright © 1974 by the American Society for Microbiology. All rights reserved.