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J Virol. 1974 August; 14(2): 203-206
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Prevention of Bacteriophage Adsorption to Staphylococcus aureus by Immunoglobulin G

Department of Clinical Bacteriology, University of Uppsala, Uppsala, Sweden

ABSTRACT

Normal human and rabbit sera when incubated with Staphylococcus aureus inhibit the adsorption of bacteriophages. The bacteriophage adsorption was also inhibited by separated normal immunoglobulin M (IgM), F(ab')₂, and Fab-fragments of IgG. No inhibition was obtained with myeloma IgG or Fc-fragments of normal human and rabbit IgG. The results indicate that the serum inhibition of bacteriophage adsorption to S. aureus is not due to a binding of IgG to protein A on the surface of S. aureus.