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J Virol. 1974 July; 14(1): 133-138
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Baboon Virus Isolate M-7 with Properties Similar to Feline Virus RD-114

Alfred Hellman, Paul T. Peebles, James E. Strickland, Arnold K. Fowler, S. S. Kalter, S. Oroszlan and R. V. Gilden

National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Southwest Foundation for Research and Education, San Antonio, Texas 78206
Flow Laboratories, Inc., Rockville, Maryland 20852

ABSTRACT

A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 virus has helper activity as demonstrated by rescue of murine sarcoma virus (MSV) from sarcoma-positive leukemia-negative human amnion cells. The host range of the rescued M-7 pseudotype of MSV, MSV (M-7), is similar to that of RD-114 virus. MSV (M-7) is also able to transform baboon cells and causes no detectable transformation of feline cells without addition of helper feline leukemia virus. Interference properties of M-7 and RD-114 virus are identical. Virus-specific neutralizing antisera, although partially cross-reacting, can distinguish MSV (M-7) from MSV (RD-114). These similarities and differences between RD-114 and M-7 viruses are best explained as type-specific differences between two viruses within the same strain.

J Virol. 1974 July; 14(1): 133-138
Copyright © 1974 American Society for Microbiology. All Rights Reserved.



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