This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tronick, S. R. Articles by Aaronson, S. A. Search for Related Content PubMed PubMed Citation Articles by Tronick, S. R. Articles by Aaronson, S. A.

 Previous Article  |  Next Article 

J Virol. 1974 July; 14(1): 125-132
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Immunological Properties of Two Polypeptides of Mason-Pfizer Monkey Virus

¹ Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

ABSTRACT

Two polypeptides were isolated from the Mason-Pfizer monkey virus (MP-MV). The polypeptides, designated MP-MV p26 and MP-MV p15, were 26,000 and 15,000 molecular weight, respectively, based on gel filtration chromatography in the presence of 6 M guanidine hydrochloride. Radioimmunoassays developed for MP-MV p26 and p15 were, respectively, 10 and 100 times more sensitive than immunodiffusion and 1 and 10 times more sensitive than micro-complement fixation for the detection of MP-MV. Antigens of other reverse transcriptase-containing RNA viruses did not cross-react in either MP-MV radioimmunoassay. Further, antisera against these other viruses did not react with the radioiodine-labeled MP-MV polypeptides. The MP-MV radioimmunoassays should be useful in studying the natural occurrence of this virus and its relationship to primate tumors.

This article has been cited by other articles:

• Andersen, P., Barbacid, M, Tronick, SR, Clark, H., Aaronson, S. (1979). Evolutionary relatedness of viper and primate endogenous retroviruses. Science 204: 318-321 [Abstract]