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J Virol. 1974 July; 14(1): 1-7
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Serological Characterization of the Three Major Proteins of Vesicular Stomatitis Virus

Bernhard Dietzschold, Lothar G. Schneider and James H. Cox

Federal Research Institute for Animal Virus Diseases, Tübingen, West Germany

ABSTRACT

The three major proteins of vesicular stomatitis virus-Indiana, glycoprotein (G), nucleoprotein (N), and membrane protein (M), were isolated and characterized by means of specific monocomponent antisera. G, N, and M proteins are distinct, nonrelated antigens with specific serological properties. The G protein is the only antigen inducing the formation of virus-neutralizing antibodies and was shown to confer immunity to mice. Specific complement-fixing and precipitating activity was demonstrated for each of the three antisera. The future use of isolated rhabdovirus components and of monospecific antisera is considered for therapeutic and diagnostic purposes as well as for virus strain differentiation and classification work.

J Virol. 1974 July; 14(1): 1-7
Copyright © 1974 American Society for Microbiology. All Rights Reserved.



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Copyright © 1974 by the American Society for Microbiology. All rights reserved.