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Endogenous C-Type Virus of a Mouse Cell Line and Its Defectiveness

Department of Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Institut du Radium, Biologie, Facultè des Sciences, Bâtiment 110, 91405-ORSAY, France
Department of Pathology, National Institute of Health, Tokyo, Japan

ABSTRACT

MLg cells originating from a newborn ddY mouse began to release C-type virus by treatment with 5-iodo-2'-deoxyuridine (5 µg/ml) for 48 h, or spontaneoulsy after prolonged cultivation. The data indicated the presence of three categories of the viruses spontaneously induced, i.e., virus equipped with the abilities of infecting and transforming the S+L- C182 cells, virus which can infect C182 cells but is unable to transform C182 cells, and virus which cannot infect nor transform the C182 cells, but is positive for the XC test. The type of the virus produced depended upon the cell clone. With the advance in the passage level, the cell population was dominated by the cells producing, uniquely, the last category of the virus.

¹ Present address: Institut du Radium, Biologie, Faculté des Sciences, Bâtiment 110, 91405-Orsay, France.