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J Virol. 1974 May; 13(5): 993-996
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Scrapie and Transmissible Mink Encephalopathy: Search for Infectious Nucleic Acid

Departments of Veterinary Science and Biochemistry and the Biophysics Laboratory, University of Wisconsin, Madison, Wisconsin 53706
Department of Plant Pathology, University of California, Riverside, California 92502

ABSTRACT

Brain preparations from animals with scrapie or transmissible mink encephalopathy were phenol extracted and examined for the presence of pathogenic nucleic acid. Animals inoculated with various extracts remained healthy, and analysis on 2.6 to 5% polyacrylamide gels failed to detect a difference in extractable RNA species between infected and normal mink brain.

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