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Poliovirus Infection and Poly(A) Sequences of Cytoplasmic Cellular RNA

Institut für Virologie der Universität, Würzburg, D8700 Würzburg, Germany

ABSTRACT

The influence of polio infection on Poly(A) sequences of cellular cytoplasmic RNA was investigated. In the presence of guanidine, cellular protein synthesis was still shut off after poliovirus infection, although there was no viral RNA synthesis. The Poly(A) of these cells was unchanged with respect to quantity, size, and linkage to cellular cytoplasmic RNA. This finding strongly suggests that the shut off of cellular protein synthesis is not caused by a change of the Poly(A) sequences of cellular mRNA.