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Location of the Origin of DNA Replication in Adenovirus Type 2

¹ Departments of Microbiology and Immunology, and Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461

ABSTRACT

Utilizing the isolated left and right halves of both adenovirus type 2 and the nondefective adenovirus simian virus 40 hybrid (Ad2⁺ND₁), studies were undertaken to find the site on the DNA molecules at which replication begins. The data are consistent with several models which include an initiation event at both ends and bidirectional growth.