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Bacteriophage Interference in Bacillus subtilis 168

^a Departments of Microbiology, Pathology, and Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

ABSTRACT

Strains of Bacillus subtilis lysogenic for temperate bacteriophage SPO2 inhibit the development of bacteriophage 1. After infection by bacteriophage 1, DNA and RNA synthesis in the lysogenic host terminates, culminating in cell death. Bacteriophage SPO2 also prevents the production of bacteriophage 105. Mechanisms for these two types of bacteriophage interference are discussed.

¹ Present address: Department of Genetics, Stanford University School of Medicine, Stanford, California 94305.