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J Virol. 1974 April; 13(4): 769-774
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Intracellular Replication of Mycoplasmavirus MVL51

^a Departments of Microbiology and of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

ABSTRACT

The intracellular replication of MVL51, a group L1 mycoplasmavirus, was investigated. The single-stranded parental DNA was found to enter the cell and become converted to double-stranded DNA. This replicated to yield additional double-stranded DNA molecules. The parental viral DNA was found to leave the replication complex and become associated with large molecular weight DNA not involved with viral replication. Progeny viral DNA formed from the double-stranded DNA and an intracellular accumulation of virus chromosome size DNA was observed. The interpretation of this data and a suggested model for the viral replication are discussed and compared to viral DNA replication models for other single-stranded DNA viruses.

¹ Present address: Department of Biology, York University, Downsview, Ontario M3J 1P3, Canada.

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