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J Virol. 1974 March; 13(3): 652-661
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

RNA Transcription by the Virion Polymerases of Five Rhabdoviruses

Institute of Microbiology, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey 08903
National Communicable Disease Center, Atlanta, Georgia 30333

ABSTRACT

The presence of a virion-associated RNA-dependent RNA polymerase in five serologically distinct rhabdovirus isolates (vesicular stomatitis virus [VSV] Indiana, VSV New Jersey, Cocal, Chandipura, and Piry viruses) has been demonstrated. The enzyme for each virus has been shown to be a transcriptase capable of synthesizing in vitro RNA which is complementary to the viral genome. By sequence analyses it has been shown that, for each rhabdovirus, transcription is multiply initiated with specific 5' nucleotide sequences. The results indicate that, for all five viruses, the initiation of transcription involves similar sequences (e.g., pppApCpGp..., pppGpCp..., and possibly one or two other sequences), suggesting relatedness and some genome conservation among these viruses.

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