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Human Cytomegalovirus II. Lack of Relatedness to DNA of Herpes Simplex I and II, Epstein-Barr Virus, and Nonhuman Strains of Cytomegalovirus

¹ Department of Medicine and Department of Bacteriology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27514

ABSTRACT

The purified DNA of human cytomegalovirus, radiolabeled in vitro, was examined for homology to Epstein-Barr virus, herpes simplex type I and II, and simian and murine cytomegalovirus DNA by DNA-DNA reassociation kinetics analyses with the S1 enzyme differential digestion technique. Cross-matching of the DNAs showed no relatedness or less than 5% detectable homology.

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• Goldstein, J. N., Weller, S. K. (1998). In Vitro Processing of Herpes Simplex Virus Type 1 DNA Replication Intermediates by the Viral Alkaline Nuclease, UL12. J. Virol. 72: 8772-8781 [Abstract] [Full Text]