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J Virol. 1974 January; 13(1): 237-240
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Oncogenicity of an Endogenous C-Type Virus Chemically Activated from Mouse Cells in Culture

John R. Stephenson, Joel S. Greenberger and Stuart A. Aaronson

1 Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

ABSTRACT

RNA C-type viruses are known to exist in an unexpressed form in all mouse cells. These endogenous viruses can be activated from cells in tissue culture under certain experimental conditions. The biologic activity in vivo of one class of chemically-activated C-type virus has been studied. This virus is shown to induce a specific tumor, lymphatic leukemia, in mice of a low leukemic incidence strain.


J Virol. 1974 January; 13(1): 237-240
Copyright © 1974 American Society for Microbiology. All Rights Reserved.







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Copyright © 1974 by the American Society for Microbiology. All rights reserved.