This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sadowski, P. D. Search for Related Content PubMed PubMed Citation Articles by Sadowski, P. D.

Suppression of a Mutation in Gene 3 of Bacteriophage T7 (T7 Endonuclease I) by Mutations in Phage and Host Polynucleotide Ligase

Division of Experimental Pathology, Department of Pathology, University of Toronto, Toronto, Canada

ABSTRACT

Bacteriophage T7 bearing amber mutations in both gene 1.3 (T7 DNA ligase) and gene 3 (T7 endonuclease I) are viable when grown in suppressor-negative, ligase-negative hosts. This is evidenced by a high plating efficiency and a large burst size compared to the single mutants. These findings may be explained by a limited destruction of cellular DNA by the double mutant.

This article has been cited by other articles:

• Bull, J., Springman, R, Molineux, I. (2007). Compensatory Evolution in Response to a Novel RNA Polymerase: Orthologous Replacement of a Central Network Gene. Mol Biol Evol 24: 900-908 [Abstract] [Full Text]  
• Rokyta, D., Badgett, M. R., Molineux, I. J., Bull, J. J. (2002). Experimental Genomic Evolution: Extensive Compensation for Loss of DNA Ligase Activity in a Virus. Mol Biol Evol 19: 230-238 [Abstract] [Full Text]