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J Virol. 1973 December; 12(6): 1209-1215
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Structure and Infectivity of Picornaviral RNA Encapsidated by Cowpea Chlorotic Mottle Virus Protein

Life Sciences Division, Stanford Research Institute, Menlo Park, California 94025
Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

ABSTRACT

Poliovirus and Mengo virus RNA were shown to associate efficiently with cowpea chlorotic mottle virus protein to form pseudovirions. The sedimentation coefficient for the pseudovirions was similar to that of poliovirus, and electron microscope observations showed the Mengo pseudovirions to be similar in size to Mengo virus. Such pseudovirions were infectious and were more resistant to ribonuclease than viral RNA; however, under our assay conditions, their infectivity was about equal to that of viral RNA.