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J Virol. 1973 September; 12(3): 588-593
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Sedimentation Changes of L Cells in a Density Gradient Early After Infection with Vaccinia Virus

Department of Bacteriology and Immunology, Health Sciences Center, University of Western Ontario, London, Ontario N6A 3K7, Canada

ABSTRACT

By 2 h postinfection, LM cells infected with vaccinia virus show a shift in their distribution when separated on a Ficoll density gradient. This shift is dependent on both time and the multiplicity of infection and is due, at least in part, to an increase in cell size. Those cells which do shift in position in the gradient represent infected members of the population. Physical changes induced in virus-infected cells can be utilized for studying early events in virus replication.