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J Virol. 1973 August; 12(2): 405-407
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Effect of Nalidixic Acid on PBS2 Bacteriophage Infection of Bacillus subtilis

Alan R. Price and Suzanne M. Fogt

1 Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48104

ABSTRACT

Infection of Bacillus subtilis by PBS2 phage, whose DNA contains uracil instead of thymine, is relatively unaffected by low concentrations of nalidixic acid which severely inhibit B. subtilis DNA synthesis. High concentrations of nalidixic acid do inhibit PBS2 DNA synthesis, but more severely reduce the burst size of PBS2 infections. Hydroxyurea blocks PBS2 DNA synthesis, preventing progeny phage production.

J Virol. 1973 August; 12(2): 405-407
Copyright © 1973 American Society for Microbiology. All Rights Reserved.





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Copyright © 1973 by the American Society for Microbiology. All rights reserved.