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J Virol. 1973 June; 11(6): 856-861
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Replication Process of the Parvovirus H-1 I. Kinetics in a Parasynchronous Cell System

¹ Putnam Memorial Hospital, Institute for Medical Research, Bennington, Vermont 05201

ABSTRACT

Parasynchronous cultures of hamster embryo cells were used to study some of the events in the replication process of the parvovirus H-1. Synthesis of viral DNA, viral hemagglutinating antigen, and infectious virus were examined. It was found that initiation of DNA synthesis, on which subsequent viral hemagglutinin synthesis was dependent, occurred at a specific time in late S-phase. Production of H-1 viral protein was shown to be sensitive to inhibition by -amanitin. The implications of these findings are discussed.

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