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J Virol. 1973 May; 11(5): 806-809
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Analysis of Nuclear Disruption and Binding of Intermediates in Host DNA Breakdown to Membranes After Infection of Escherichia coli with Bacteriophages T4 and T7 ¹

Department of Biochemistry and Department of Genetics and Cell Biology, College of Biological Sciences, University of Minnesota, St. Paul, Minnesota 55101
Department of Microbiology and School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455

ABSTRACT

Escherichia coli DNA polymerase I is implicated in the binding of intermediates in host DNA breakdown to membrane in T4-infected, but not T7-infected, cells. Nuclear disruption is observed in T4-infected polA1 mutant cells.

¹ This publication is Scientific Paper no. 8179 of the Minnesota Agricultural Experiment Station.