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J Virol. 1973 February; 11(2): 287-298
Copyright © 1973 American Society of Microbiology. All Rights Reserved.

Analysis of High-Molecular-Weight Ribonucleic Acid Associated with Intracisternal A Particles

Stringner Sue Yang and Nelson A. Wivel

1 Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

ABSTRACT

Intracisternal A particles, known primarily for their association with various tumors, have been shown to contain high-molecular-weight (HMW) ribonucleic acid (RNA) by velocity centrifugation, using linear glycerol gradients. This HMW RNA is sensitive to ribonuclease digestion and alkali treatment but is resistant to Pronase treatment. By a double-labeling experiment, HMW RNA was shown to be intrinsic to intracisternal A particles and not to have resulted from cytoplasmic polysomal RNA aggregation. By a reconstitution experiment, it was determined that the results were not due to C-type virus contamination. The synthesis of HMW RNA in intracisternal A particles is inhibited by actinomycin D and ethidium bromide. These observations emphasize that there are probably some taxonomic relationships between intracisternal A particles and oncogenic RNA viruses.

J Virol. 1973 February; 11(2): 287-298
Copyright © 1973 American Society of Microbiology. All Rights Reserved.



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