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J Virol. 1973 February; 11(2): 232-237
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Effect of Viral Double-Stranded RNA on Protein Synthesis in Intact Cells

B. Cordell-Stewart and Milton W. Taylor

1 Department of Microbiology, Indiana University, Bloomington, Indiana 47401

ABSTRACT

The addition of purified, noninfectious, double-stranded RNA of bovine enterovirus, a picornavirus, to intact cells in culture results in a rapid cessation of cellular polypeptide synthesis. This inhibition is specific for host cell protein synthesis since the translation of picornavirus-specific proteins is not affected by the double-stranded viral RNA.

J Virol. 1973 February; 11(2): 232-237
Copyright © 1973 American Society for Microbiology. All Rights Reserved.



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Copyright © 1973 by the American Society for Microbiology. All rights reserved.