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J Virol. 1973 January; 11(1): 54-60
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Patterns of Simian Virus 40 Deoxyribonucleic Acid Transcription II. In Transformed Cells

¹ Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

ABSTRACT

The pattern of simian virus 40 (SV40) deoxyribonucleic acid transcription has been examined in 11 SV40-transformed cell lines. In all cases, substantial regions of the minus strand (35-75%) appeared to be transcribed. In the lines tested, these regions included the "early" gene sequences. The SV40-specific ribonucleic acid from at least two of the transformed cell lines represented significantly greater portions of the minus strand than are represented in "early" lytic ribonucleic acid. Small regions of the plus strand appeared to be transcribed in only two of the transformed cell lines.