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J Virol. 1972 December; 10(6): 1205-1207
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Asymmetric Transcription of Bacteriophage Mu-1

¹ Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724

ABSTRACT

The deoxyribonucleic acid (DNA) of bacteriophage Mu-1 can be separated into its complementary strands by poly(U,G) binding and equilibrium centrifugation. DNA-ribonucleic acid (RNA) hybridizations in liquid show that more than 98% of "early" phage-specific RNA and over 96% of "late" messenger species bind to the heavy [poly(U,G)-binding] strand of Mu-1 DNA. A small (1.45%) but significant amount of late RNA binds to the light strand. The significance of this RNA fraction is discussed in connection with the peculiar structure of denatured and reannealed Mu-1 DNA.

This article has been cited by other articles:

• Howe, M., Bade, E. (1975). Molecular biology of bacteriophage mu. Science 190: 624-632