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J Virol. 1972 December; 10(6): 1152-1158
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Binding of Bacteriophage P22 Tail Parts to Cells

^a Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48104

ABSTRACT

Purified base-plate parts of bacteriophage P22 can bind to the host cell, Salmonella typhimurium. Although the reaction is reversible, a stable equilibrium is not formed between bound and unbound base-plate parts. This is because the binding sites on the cell, presumably the O antigens, are destroyed. The destruction of binding sites does not kill the cells, and, in fact, the binding sites are soon regenerated. The site-destroying activity reacts with P22 heads to make active phage and with antiserum made against purified phage. Therefore site-destroying activity is a characteristic of the base-plate parts and not some contaminant of the preparation.

¹ Present address: Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, Ga. 30902.

² Present address: Department of Botany, California State College at Los Angeles, Los Angeles, Calif. 90032.

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