This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Furlong, D. Articles by Roizman, B. Search for Related Content PubMed PubMed Citation Articles by Furlong, D. Articles by Roizman, B.

 Previous Article  |  Next Article 

J Virol. 1972 November; 10(5): 1071-1074
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Arrangement of Herpesvirus Deoxyribonucleic Acid in the Core

Departments of Microbiology and Biology, The University of Chicago, Chicago, Illinois 60637

ABSTRACT

The core of the herpes simplex virion consists of an electron-dense toroidal structure 50 nm high, with an inside diameter of 18 nm and an outside diameter of 70 nm, penetrated by a less dense cylindrical mass. The toroid contains deoxyribonucleic acid (DNA), as evident from the observation that uranyl ion staining is removed by ethylenediaminetetraacetic acid under conditions which result in the extraction of uranyl ions bound to nuclear DNA. Studies on negatively stained preparations of purified capsids suggest that the toroid consists of DNA arranged as if it were spooled around the cylindrical mass.

This article has been cited by other articles:

• Zhou, Z. H., Chen, D. H., Jakana, J., Rixon, F. J., Chiu, W. (1999). Visualization of Tegument-Capsid Interactions and DNA in Intact Herpes Simplex Virus Type 1 Virions. J. Virol. 73: 3210-3218 [Abstract] [Full Text]