This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mortelmans, K. Articles by Friedberg, E. C. Search for Related Content PubMed PubMed Citation Articles by Mortelmans, K. Articles by Friedberg, E. C.

 Previous Article  |  Next Article 

J Virol. 1972 October; 10(4): 730-736
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Deoxyribonucleic Acid Repair in Bacteriophage T4: Observations on the Roles of the x and v Genes and of Host Factors

Department of Pathology and Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California 94305

ABSTRACT

Studies were carried out to determine the effect of mutation in the host pol I gene on survival of ultraviolet (UV)-irradiated bacteriophage T4. Whereas a slightly reduced survival was observed in Escherichia coli strain P-3478 (pol A₁) compared to strain W-3110 (pol A⁺), no such difference was observed in two strains isogenic except for the pol A gene. It was also shown that, whereas bacteriophage T4x is sensitive to UV irradiation, X irradiation, and treatment with methyl-methanesulfonate (MMS), phage T4v₁ is sensitive only to UV irradiation. The survival of damaged phage T4x is neither affected by the presence of the rec A, rec B, or pol A mutations in the host, nor is there evidence that phage T4 effects repair of rec A or pol A mutants previously treated with either UV or MMS.

This article has been cited by other articles:

• Clyman, J, Belfort, M (1992). Trans and cis requirements for intron mobility in a prokaryotic system.. Genes Dev. 6: 1269-1279 [Abstract]