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J Virol. 1972 October; 10(4): 653-657
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Isolation of Temperature-Sensitive Mutants of Murine Sarcoma Virus

Edward M. Scolnick, John R. Stephenson and Stuart A. Aaronson

1 Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014

ABSTRACT

Three separate murine sarcoma virus nonproducer cell lines have been isolated which are temperature sensitive for the maintenance of transformation. In each case, a viral rather than a cellular genetic mutation is the reason for the temperature-sensitive effect. Superinfection of one of the mutants with murine leukemia virus overcomes the temperature-sensitive change in the transformed state.

J Virol. 1972 October; 10(4): 653-657
Copyright © 1972 American Society for Microbiology. All Rights Reserved.



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