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J Virol. 1972 July; 10(1): 124-133
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Nuclear Disruption After Infection of Escherichia coli with a Bacteriophage T4 Mutant Unable to Induce Endonuclease II

Department of Genetics and Cell Biology and Department of Biochemistry, College of Biological Sciences, University of Minnesota, St. Paul, Minnesota 55101
Department of Microbiology and School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455

ABSTRACT

Nuclear disruption after infection of Escherichia coli with a bacteriophage T4 mutant deficient in the ability to induce endonuclease II indicates that either (i) the endonuclease II-catalyzed reaction is not the first step in host deoxyribonucleic acid (DNA) breakdown or (ii) nuclear disruption is independent of nucleolytic cleavage of the host chromosome. M-band analysis demonstrates that the host DNA remains membrane-bound after infection with either an endonuclease II-deficient mutant or T4 phage ghosts.