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J Virol. 1967 December; 1(6): 1164-1167
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Interferon Production in Mice by Cell Wall Mutants of Salmonella typhimurium

¹ Department of Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15123

ABSTRACT

The interferon response elicited by Salmonella typhimurium mutants in mice is not dependent on the presence of a complete cell wall lipopolysaccharide. In fact, a mutant (G30/C21) which has lost all the polysaccharide side chains and sugars of the O antigen and contains only 2-keto-3-deoxyoctonate and lipid is indistinguishable in its interferon-stimulating ability from the wild type which possesses a complete O antigen with polysaccharide side chains.