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J Virol. 1967 December; 1(6): 1158-1163
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Analysis of Additional Interference Occurring After the Removal of Interferon ¹

^a Central Research Department, Experimental Station, E. I. du Pont de Nemours and Company, Wilmington, Delaware 19898

ABSTRACT

Cultures of chick cells exposed to interferon continued to decrease in virus-producing ability during incubation after the interferon was removed. The rate of development of the additional interference and the degree of viral interference finally manifested were dependent on the concentration of interferon to which the cultures were exposed and the time of exposure. Additional interference occurred also in infected cells. Additional interference was inhibited by actinomycin D and puromycin. The best explanation of additional interference is that it results from interferon that is fixed to the cells during their initial period of contact.

¹ This work was done while the author was a member of the faculty of the Department of Microbiology, The University of Texas, Austin.

This article has been cited by other articles:

• Ryser, H. J.-P. (1968). Uptake of Protein by Mammalian Cells: An Underdeveloped Area: The penetration of foreign proteins into mammalian cells can be measured and their functions explored. Science 159: 390-396 [Abstract]