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Growth Curve and Distribution of Rous Sarcoma Virus (Bryan) in Japanese Quail ¹

^a Institute of Microbiology, Rutgers, The State University, New Brunswick, New Jersey, 08903

ABSTRACT

On primary infection with the Bryan strain of Rous sarcoma virus (RSV), the growth curve of the virus in the brain of Japanese quail was similar to that observed in chicks and turkey poults. Infectious virus disappeared from the brain after inoculation. After an eclipse period during which no virus was detectable, infectious virus began to appear at 2 days and reached maximal titers in the brain samples at 7 days after inoculation. When Japanese quail were infected intracerebrally with RSV, relatively high titers of virus were recovered from brain tissue but not from liver, lung, kidney, or blood of moribund birds. Only tumors produced in the wing web of quail infected subcutaneously yielded high titers of virus. Other tissues yielded no virus, even though wing web tumors appeared as early as in chicks similarly infected. RSV could be propagated in the wing web of quail for at least 14 passages without any loss of infectivity. On the other hand, serial passage in quail brain resulted in a progressive loss of infectivity until virus was completely lost.

² Present address: Department of Pathology, University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston, Tex. 77025.

¹ A preliminary report of these data was presented at the 67th Annual Meeting of the American Society for Microbiology, New York, N.Y., 2 May 1967.

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