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Nonproducing State of Rous Sarcoma Cells: Its Contagiousness in Chicken Cell Cultures

^a Department of Pathology, University of Colorado Medical School, Denver, Colorado 80220

ABSTRACT

Nonproducing Rous sarcoma cells of the chicken were capable of transmitting the Rous sarcoma virus genome to neighboring chick embryo fibroblasts. This transfer required close proximity of sarcoma and normal cells and may have been mediated by a subcellular infectious agent which was found to be released from nonproducing cells.

¹ Present address: Department of Microbiology, University of Washington Medical School, Seattle 98105.