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J Virol. 1967 April; 1(2): 384-399
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Electron Microscopic Study of the Development of Simian Virus 40 by Use of Ferritinlabeled Antibodies

^a Department of Microbiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032

ABSTRACT

An electron microscopic study of simian virus 40 has revealed a number of structural changes that are related to the development of the virus. The presence of viral antigens in both the nucleus and the cytoplasm has been demonstrated by means of ferritin-labeled antibodies. Although cytoplasmic virions are readily tagged, the lack of tagging of nuclear particles presents a perplexing problem. Presumably, the virus, after release from the nucleus, acquires a new antigenic reactivity in the cytoplasm.

¹ Postdoctoral Public Health Service Fellow (PHS-1F2-AI-30042). Present address: Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley.