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J Virol. 1967 February; 1(1): 135-144
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

The Process of Infection with Bacteriophage øX174 XIII. Evidence for an Essential Bacterial "Site" ¹

^a Division of Biology, California Institute of Technology, Pasadena, California

ABSTRACT

The burst of a starved bacterium infected with several øX174 bacteriophage was usually found to contain genetic traits of only one of the possible parents; less often, two phage multiplied in the same host cell. Unstarved cells, in contrast, supported the growth of at least four parental phage types. The unproductive phage seemed to be able to undergo the intracellular transition from parental single-stranded deoxyribonucleic acid to the double-stranded "replicative form" (RF). These results are taken to mean that some bacterial factor required for a step between RF synthesis and maturation of progeny is limited in starved cells.

² Present address: Department of Biochemistry, Stanford University School of Medicine, Palo Alto, Calif.

¹ From a thesis submitted by M. Yarus to the California Institute of Technology in partial fulfillment of the requirements for the Ph.D. degree.