FIG. 2. Replication of CDV in different body fluids and the brain. (A) Number of CDV-infected cells or infectious units in PBMC, urine, and CSF. The cell associated virus titer in the PBMC is expressed as TCID₅₀ per million cells, and the cell-free virus titer in urine and CSF is expressed as TCID₅₀ per ml. (B to G) Visualization of infection in the brain at the end stage of the disease. (B and C) Ventral view of the brain by (B) normal light or (C) EGFP fluorescence excitation. Contours are outlined with a white line. (D and E) Dorsal views of the same sample. (F and G) Saggital cut separating the left and right hemispheres.